|
KMID : 0376219950310010069
|
|
Chonnam Medical Journal
1995 Volume.31 No. 1 p.69 ~ p.78
|
|
|
Prognostic and therapeutic significance of the flow cytometric DNA analysis in small cell lung cancer
|
|
Kang Yoo-Ho
Chung Ik-Joo
Kim Young-Chul
Choi In-Seon
Park Kyung-Ok
Kim Hyeoung-Joon
|
|
|
Abstract
|
|
|
|
To evaluate prognostic and therapeutic significance, tumor DNA content(Ploidy) and proliferative activity(percentage of cells in S and G2/M portion was determined by flow cytometry paraffin-embedded samples obtained from 30 patients with small cell lung cancer. Forty-six percent(46%) patients had DNA aneuploid patterns that did not seem to be a good prognosticator for survival. Patients whose tumor showed a high proliferative activity(S+G2/M>22%) and) did not die earlier. The response rate to therapy did not depend on DNA ploidy or proliferative activity. These results indicate that DNA content or proliferative activity is not the independant prognostic factor in small cell lung cancer.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|